Skip to content

Your Cart

Your cart is empty

Continue shopping

Free Sample

Select your free sample below
Supreme Night Secret Sample
Supreme Night Secret Sample
FREE
Instant Fix Eye Lift Gel Sample
Instant Fix Eye Lift Gel Sample
FREE
Supreme Day Cream Sample
Supreme Day Cream Sample
FREE
Deep Exfoliating Mask Sample
Deep Exfoliating Mask Sample
FREE
High Maintenance Cream Sample
High Maintenance Cream Sample
FREE
Vitamin C Brightening Primer SPF15 Sample
Vitamin C Brightening Primer SPF15 Sample
FREE
Deep Exfoliating Mask Sensitive Skin Sample
Deep Exfoliating Mask Sensitive Skin Sample
FREE
Skin Perfecting Mask Sample
Skin Perfecting Mask Sample
FREE
Rose de Vie Cream Cleanser Sample
Rose de Vie Cream Cleanser Sample
FREE
Skin Perfecting Cream Sample
Skin Perfecting Cream Sample
FREE
Replenishing Cream Sample
Replenishing Cream Sample
FREE
Vital Cream Sample
Vital Cream Sample
FREE

Signature Serum

Advanced longevity serum powered by biotech to improve firmness, boost cellular energy and protect against environmental ageing

“From the very first time you apply this luxurious serum you will discover a marked difference in the way your skin looks - it immediately feels softer, plumper and looks more radiant. Apply morning and just before bed to clean skin for maximum benefit.”Dr Sebagh

Sale price£250.00 Regular price£475.00

Price per ml: £8.33/ml

Suitable For

  • Gray circle with a white plus sign in the centerAll Skin Types
  • Gray circle with a white plus sign in the centerMature Skin
  • Gray circle with a white plus sign in the centerUrban / City Skin

Targets

  • Gray circle with a white plus sign in the centerSkin Hydration
  • Gray circle with a white plus sign in the centerFine Lines & Wrinkles
  • Gray circle with a white plus sign in the centerDamaged Skin Barrier
<p>Earn%20[points_amount]%20when%20completing%20this%20purchase.</p>

Dr Sebagh's most advanced longevity serum, developed over five years for the clients of his private clinic. Biotech actives Chronodyn and Juvinity work at the heart of the skin cell, supporting cellular energy and helping to slow the pace at which skin ages, while an anti-pollution shield defends against the oxidative stress that accelerates it.

Skin appears smoother, firmer and more radiant. Most potent at night, when the skin's own regenerative rhythm is at work.

Key Ingredients and Actives

Euglena Gracilis Extract (Chronodyn)

a pseudo algae that works with the skin’s overnight restorative cycle, known as the ‘cutaneous biological clock’, to increase the release of calcium and production of ATP (adenosine triphosphate) molecules, helping tone and re-firm the skin and erase the signs of fatigue.

Juvinity

This pioneering active ingredient combats the ageing of the cell’s nucleus, encouraging it to behave like a young cell and so delaying the metabolic and nucleus senescence (the process of deterioration with age). It also limits oxidative stress and Telomeres shortening to ensure optimum metabolism and the replication of young cells.

Hyaluronic Acid

This powerful humectant, which is naturally present in the skin, both attracts and retains moisture within the epidermis. It can hold many times its own weight, acting like a sponge to ensure skin is effectively hydrated, plumped and fresh-looking.

Alpha-Glucan Oligosaccharide

a natural prebiotic that protects and stimulates beneficial microbial skin flora. Also known to have antioxidant benefits and to stimulate the antimicrobial peptides released by skin cells.

Sesame Seed Oil

rich in nourishing fatty acids, including oleic and linoleic acids. Repairs and regenerates the skin's essential barrier.

Wheat Germ Oil

one of the highest concentrations of antioxidant Vitamin E in any plant oil. Rich in moisturising fatty acids to moisturise and repair the skin's essential barrier.

Phoenix Dactylifera (Date) Seed Extract

a plant-derived active ingredient extracted from the date-palm kernel. A source of isoflavones, ursolic acid, phytosterols, antioxidant tocotrienols and Vitamin A. Improves skin elasticity, stimulates fibroblasts and collagen production, increased skin hydration and an anti-inflammatory effect. Proven to have a significant impact on the visible signs of skin ageing, including the appearance of fine lines and wrinkles.

Rapeseed Sterols

plant sterols (phytosterols) have been shown to inhibit enzymes which degenerate collagen fibres, slowing the loss of elasticity that comes with age. Promotes cellular regeneration, boosting collagen and hyaluronic acid synthesis to repair the skin barrier, reducing TEWL. Also known to have skin-soothing, anti-inflammatory benefits.

Tocopherol

also known as Vitamin E. A strong antioxidant with emollient properties that is easily absorbed by our skin to reduce oxidative stress caused by free radicals.

Biosaccharide Gum-4

provides anti-pollution benefits, helping to protect skin against external aggressors. This polysaccharide, extracted from corn, forms a three-dimensional matrix which acts like a suit of armour and helps to shield the skin against atmospheric pollution.

AQUA (WATER), ISONONYL ISONONANOATE, DIPENTAERYTHRITYL HEXACAPRYLATE/HEXACAPRATE, CAPRYLIC/CAPRIC TRIGLYCERIDE, EUGLENA GRACILIS EXTRACT, DIMETHYL ISOSORBIDE, ISOSTEARYL ISOSTEARATE, BIOSACCHARIDE GUM-4, DIMETHICONE, PHENOXYETHANOL, CAPRYLIC/CAPRIC/SUCCINIC TRIGLYCERIDE, LAUROYL LYSINE, SODIUM POLYACRYLATE, RHIZOBIAN GUM, SODIUM HYALURONATE, ALPHA-GLUCAN OLIGOSACCHARIDE, PROPANEDIOL, CHLORPHENESIN, DIMETHICONE/VINYL DIMETHICONE CROSSPOLYMER, CAPRYLYL GLYCOL, GLYCERIN, SESAMUM INDICUM (SESAME) SEED OIL, PEG-20 SORBITAN COCOATE, AROMA (FLAVOR), TRITICUM VULGARE (WHEAT) GERM OIL, ALGIN, GERANYLGERANYLISOPROPANOL, PHOENIX DACTYLIFERA (DATE) SEED EXTRACT, TOCOPHERYL ACETATE, TRIDECETH-6, BRASSICA CAMPESTRIS (RAPESEED) STEROLS, POTASSIUM SORBATE, CITRONELLOL, BENZYL ALCOHOL, TOCOPHEROL, GERANIOL, CI 14700 (RED4).

Application

After cleansing apply to the face at night. For maximum benefit, blend with other serums from the Serum Bar and shake well before use.

Benefits
  • Works with the skin's regenerative processes which occur at night to prevent skin cell deterioration.
  • Telomere technology helpers reduce and slow cellular ageing
  • Boosts cellular energy (ATP)to revitalise tired-looking skin
  • Protects against environmental stressors with an anti-pollution shield
  • Improves skin firmness, collagen and skin density
  • Deeply hydrates and improves skin comfort
  • Reinforces the skin barrier and microbiome
  • Supports skin longevity with advanced biotech actives
  • Helps calm inflammation and support detoxification
FAQs

What is Signature Serum and how is it different from a regular anti-ageing serum?

Signature Serum is an advanced longevity serum powered by biotech ingredients that work at a cellular level. Rather than only targeting visible signs of ageing, it supports the skin’s natural repair processes, boosts cellular energy, and helps maintain youthful skin function over time.

What does skin longevity mean in skincare?

Skin longevity refers to maintaining the health, function and appearance of skin cells for longer. Signature Serum supports this by protecting the skin cell nucleus, boosting energy (ATP), and helping reduce the effects of environmental and oxidative stress that accelerate ageing.

Can I use Signature Serum every day?

Yes, Signature Serum is designed for daily use, both morning and evening. It supports overnight repair while also protecting the skin during the day from pollution and environmental damage.

Is Signature Serum suitable for all skin types?

Signature Serum is suitable for most skin types, particularly normal, dry, mature or environmentally stressed skin. It is not recommended for very oily or acne-prone skin.

What are the key benefits of Signature Serum?

Signature Serum helps improve skin firmness, elasticity and hydration, supports the skin barrier and microbiome, protects against pollution, reduces visible signs of ageing, and promotes a healthier, more resilient complexion.

Can I layer Signature Serum with other serums?

Yes, Signature Serum is designed to be used alone or blended with other Dr Sebagh serums. It works particularly well with hydrating, anti-ageing and brightening formulas as part of a personalised skincare routine.

When should I use Signature Serum in my routine?

Apply Signature Serum after cleansing and before your moisturiser. It can be used both morning and night for optimal results.

Does Signature Serum help with environmental damage and pollution?

Yes, the formula includes anti-pollution technology that helps protect the skin from environmental aggressors such as pollution and oxidative stress, which are key contributors to premature ageing.

Is Signature Serum suitable for mature skin?

Yes, Signature Serum is particularly beneficial for mature skin or anyone experiencing loss of firmness, elasticity or advanced signs of ageing.

Can Signature Serum be used with retinol or vitamin C?

Yes, Signature Serum works well alongside active ingredients such as retinol and vitamin C. It helps support the skin barrier and improve tolerance, making it an excellent addition to a results-driven skincare routine.

How long does it take to see results?

Skin can appear more hydrated, smooth and radiant almost immediately. Improvements in firmness, elasticity and overall skin quality become more visible with consistent use over time.

Does Signature Serum help support the skin barrier?

Yes, the formula contains essential fatty acids and microbiome-supporting ingredients that help strengthen the skin barrier, reduce moisture loss and improve overall skin resilience.

Dr Sebagh Signature Serum 30ml, silver airless pump bottle
Signature Serum30ml (Regular) / Go box-free & save! Sale price£250.00 Regular price£475.00

Compare With...

Dr Sebagh Signature Serum 30ml, silver airless pump bottleSignature Serum
  • Cellular Longevity Biotechnology

    Pioneering actives combat nucleus ageing and extend DNA lifespan for younger-behaving skin.

  • Works With Your Skin's Biological Clock

    Syncs with the skin's overnight restorative cycle for maximum regenerative results while you sleep.

  • Delays Cellular Ageing at the Source

    Prevents Telomere shortening to support optimum cell metabolism and long-term skin renewal.

  • Anti-Pollution Shield

    Biosaccharide Gum-4 forms a protective matrix to shield skin from pollutant particles and external aggressors.

  • Targets Dynamic Wrinkles & Expression Lines

    A Botox-like peptide complex reduces muscle contraction for visibly smoother skin.

  • Intensive Treatment for Mature Skin

    Can be used daily, or as a concentrated 4-week course designed for advanced signs of ageing and loss of firmness.

  • 24K Gold & Platinum Nano-Technology

    Precious metals inspired by the Nefertiti Lift deliver visible firming and lifting.

  • Instant Golden Radiance

    Subtle light-reflecting gold pigments illuminate and brighten from first application.

Blog posts

View all
View all
  • 5 stars: 4 (36%)
  • 4 stars: 5 (45%)
  • 3 stars: 2 (18%)
  • 2 stars: 0 (0%)
  • 1 star: 0 (0%)
G
Grace

Amaxzing product and visible results

A
Adele R.
The best serum ever.

I've always loved this serum which has , apart from the occasional sample, been out of reach. It really changes, moisturises your skin. Has an added dimension tho - plumping of the skin and a subtle glow.

T
TWLJMEJN L.j.
Stunning

Skin really depends on skin care. It is very important to find the right skin care products. I recommend this product to tighten and moisturize the skin.

S
Stella Y.
The best of the best

I love love love signature serum so much.The result is amazing and I'll be 55 next yr... have no botox, filer not even plastic surgery but using Dr Sebagh products as my skincare regime. ❤️

C
Christina
Works

I had a travel size of both the signature serum and gold serum. At the time I started using them I was out of the other lotions and products I normally order from Dr. Sebagh and had no expectations other than not wanting my skin to feel cracked. I am empressed in the results. I do use the lotions etc but this upped the texture of my skin. Instead of being 60ish looking 50ish I'm 60ish looking 40ish. Nice.

B
Billy E.
Flight Attendant review

Used this serum as part of my night time regime. The active ingredients are more active at night and wake up feeling so much more refreshed after a long flight.
You only need a small amount as it goes a long way.
Little tip.....use in conjunction with Instant V Lift Serum according to its instructions for even better results.

B
Billy E.
Flight Attendant review

Used this serum as part of my night time regime. The active ingredients are more active at night and wake up feeling so much more refreshed after a long flight.
You only need a small amount as it goes a long way.
Little tip.....use in conjunction with Instant V Lift Serum according to its instructions for even better results.

G
Genea
Fantastic Product!!

This product is one of the best beauty products I've ever used! Definitely makes my skin feel lush, and VERY smooth. I'm in my 50's, and after using this product for a week, I feel like my skin in the best it's been in years!! I will be a life-long user of this product.

Thank you!!

T
Teresa
Brilliant product

I started using the Signature Serum a week ago and was astonished by the immediate effect. My 69-year old skin positively glowed and lines seem to become relaxed from the first application. Make up just slides on smoothly (I even seem to need less foundation as my own skin appears healthier and fresher). I've been using Dr Sebagh skin care for a couple of years now. They're all brilliant but the Signature Serum sets new standards. Yes it's expensive, and I think I may have to revert to Serum Repair for a few months when its all gone before I can bring myself to spend so much money again, but I undoubtedly will be back. It's magic in a phial. Thank you Dr Sebagh

J
Joanne
This Is The One

If you are going to spend this kind of money, this is the serum to purchase! The result is substantial and immediate. I love it. I would love it more often if they could ease up on the price a bit.

T
Trish
Ordered $830.00 serum with no instructions or free gifts

I just purchased this product when placing a phone order to the Chicago, IL Barneynsnewyork Store. I spend thousands on Dr. Sebaugh products often at Barneys! I was planning on restocking several Dr. Sebaugh items and several new items I had read about on-line and quite disappointed the Barneys in Chicago hadn't called me in awhile to inform me of the new & larger Dr. Sebaugh items. On my own DEMAND (as I was geared to other lines from SA ) I reordered some of my regular Dr. Sebaugh products and with NO OFFER OR HELP OR ADVICE FROM SA ordered the $830.00 SIGNATURE SERUM which came with no directions, except for a card. Read this card & live in IOWA !! So...with that sad news I also read that had I ordered thru this website I would have received FREE GIFTS ALONG WITH MY ORDER OF SIGNATURE SERUM that I happened to buy in Chicago Barneys-never again ( Chigago SA's beyond terrible!) My mistake as I just ordered from Chocago store & not thru your site. Do u ever send out the gifts without order thru website since it is $830 and unfortunately I'll never be able to get an appt of my dreams?