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Signature Serum

“From the very first time you apply this luxurious serum you will discover a marked difference in the way your skin looks - it immediately feels softer, plumper and looks more radiant. Apply morning and just before bed to clean skin for maximum benefit.”Dr Sebagh

Sale price£475.00

Suitable For

  • Gray circle with a white plus sign in the centerAll Skin Types
  • Gray circle with a white plus sign in the centerMature Skin
  • Gray circle with a white plus sign in the centerUrban / City Skin

Targets

  • Gray circle with a white plus sign in the centerSkin Hydration
  • Gray circle with a white plus sign in the centerFine Lines & Wrinkles
  • Gray circle with a white plus sign in the centerDamaged Skin Barrier

Dr Sebagh Signature Serum is an advanced longevity serum powered by cutting-edge biotechnology to support cellular energy, skin regeneration and long-term skin health.

Developed over five years for Dr Sebagh’s private clinic, this high-performance formula works at the heart of the skin cell to help maintain youthful function and visibly reduce the signs of ageing.

By night, it supports the skin’s natural regenerative rhythm, helping to boost cellular energy (ATP), reinforce repair processes and improve firmness, elasticity and skin density. By day, it helps protect the skin from pollution and oxidative stress, key contributors to premature ageing.

Formulated with advanced biotech actives including Chronodyn and Juvinity, alongside hyaluronic acid and essential fatty acids, this intelligent serum helps strengthen the skin barrier, support the microbiome and improve overall skin resilience.

Skin appears smoother, firmer and more radiant, with improved hydration, comfort and long-term vitality.

For enhanced results, pair with our Vitamin C booster in the morning for antioxidant protection, and incorporate a retinol treatment in the evening to support skin renewal and longevity.

Key Ingredients and Actives

Euglena Gracilis Extract (Chronodyn)

a pseudo algae that works with the skin’s overnight restorative cycle, known as the ‘cutaneous biological clock’, to increase the release of calcium and production of ATP (adenosine triphosphate) molecules, helping tone and re-firm the skin and erase the signs of fatigue.

Juvinity

This pioneering active ingredient combats the ageing of the cell’s nucleus, encouraging it to behave like a young cell and so delaying the metabolic and nucleus senescence (the process of deterioration with age). It also limits oxidative stress and Telomeres shortening to ensure optimum metabolism and the replication of young cells.

Hyaluronic Acid

This powerful humectant, which is naturally present in the skin, both attracts and retains moisture within the epidermis. It can hold many times its own weight, acting like a sponge to ensure skin is effectively hydrated, plumped and fresh-looking.

Alpha-Glucan Oligosaccharide

a natural prebiotic that protects and stimulates beneficial microbial skin flora. Also known to have antioxidant benefits and to stimulate the antimicrobial peptides released by skin cells.

Sesame Seed Oil

rich in nourishing fatty acids, including oleic and linoleic acids. Repairs and regenerates the skin's essential barrier.

Wheat Germ Oil

one of the highest concentrations of antioxidant Vitamin E in any plant oil. Rich in moisturising fatty acids to moisturise and repair the skin's essential barrier.

Phoenix Dactylifera (Date) Seed Extract

a plant-derived active ingredient extracted from the date-palm kernel. A source of isoflavones, ursolic acid, phytosterols, antioxidant tocotrienols and Vitamin A. Improves skin elasticity, stimulates fibroblasts and collagen production, increased skin hydration and an anti-inflammatory effect. Proven to have a significant impact on the visible signs of skin ageing, including the appearance of fine lines and wrinkles.

Rapeseed Sterols

plant sterols (phytosterols) have been shown to inhibit enzymes which degenerate collagen fibres, slowing the loss of elasticity that comes with age. Promotes cellular regeneration, boosting collagen and hyaluronic acid synthesis to repair the skin barrier, reducing TEWL. Also known to have skin-soothing, anti-inflammatory benefits.

Tocopherol

also known as Vitamin E. A strong antioxidant with emollient properties that is easily absorbed by our skin to reduce oxidative stress caused by free radicals.

Biosaccharide Gum-4

provides anti-pollution benefits, helping to protect skin against external aggressors. This polysaccharide, extracted from corn, forms a three-dimensional matrix which acts like a suit of armour and helps to shield the skin against atmospheric pollution.

AQUA (WATER), ISONONYL ISONONANOATE, DIPENTAERYTHRITYL HEXACAPRYLATE/HEXACAPRATE, CAPRYLIC/CAPRIC TRIGLYCERIDE, EUGLENA GRACILIS EXTRACT, DIMETHYL ISOSORBIDE, ISOSTEARYL ISOSTEARATE, BIOSACCHARIDE GUM-4, DIMETHICONE, PHENOXYETHANOL, CAPRYLIC/CAPRIC/SUCCINIC TRIGLYCERIDE, LAUROYL LYSINE, SODIUM POLYACRYLATE, RHIZOBIAN GUM, SODIUM HYALURONATE, ALPHA-GLUCAN OLIGOSACCHARIDE, PROPANEDIOL, CHLORPHENESIN, DIMETHICONE/VINYL DIMETHICONE CROSSPOLYMER, CAPRYLYL GLYCOL, GLYCERIN, SESAMUM INDICUM (SESAME) SEED OIL, PEG-20 SORBITAN COCOATE, AROMA (FLAVOR), TRITICUM VULGARE (WHEAT) GERM OIL, ALGIN, GERANYLGERANYLISOPROPANOL, PHOENIX DACTYLIFERA (DATE) SEED EXTRACT, TOCOPHERYL ACETATE, TRIDECETH-6, BRASSICA CAMPESTRIS (RAPESEED) STEROLS, POTASSIUM SORBATE, CITRONELLOL, BENZYL ALCOHOL, TOCOPHEROL, GERANIOL, CI 14700 (RED4).

Application

After cleansing apply to the face at night. For maximum benefit, blend with other serums from the Serum Bar and shake well before use.

Benefits
  • Works with the skin's regenerative processes which occur at night to prevent skin cell deterioration.
  • Telomere technology helpers reduce and slow cellular ageing
  • Boosts cellular energy (ATP)to revitalise tired-looking skin
  • Protects against environmental stressors with an anti-pollution shield
  • Improves skin firmness, collagen and skin density
  • Deeply hydrates and improves skin comfort
  • Reinforces the skin barrier and microbiome
  • Supports skin longevity with advanced biotech actives
  • Helps calm inflammation and support detoxification
FAQs

What is Signature Serum and how is it different from a regular anti-ageing serum?

Signature Serum is an advanced longevity serum powered by biotech ingredients that work at a cellular level. Rather than only targeting visible signs of ageing, it supports the skin’s natural repair processes, boosts cellular energy, and helps maintain youthful skin function over time.

What does skin longevity mean in skincare?

Skin longevity refers to maintaining the health, function and appearance of skin cells for longer. Signature Serum supports this by protecting the skin cell nucleus, boosting energy (ATP), and helping reduce the effects of environmental and oxidative stress that accelerate ageing.

Can I use Signature Serum every day?

Yes, Signature Serum is designed for daily use, both morning and evening. It supports overnight repair while also protecting the skin during the day from pollution and environmental damage.

Is Signature Serum suitable for all skin types?

Signature Serum is suitable for most skin types, particularly normal, dry, mature or environmentally stressed skin. It is not recommended for very oily or acne-prone skin.

What are the key benefits of Signature Serum?

Signature Serum helps improve skin firmness, elasticity and hydration, supports the skin barrier and microbiome, protects against pollution, reduces visible signs of ageing, and promotes a healthier, more resilient complexion.

Can I layer Signature Serum with other serums?

Yes, Signature Serum is designed to be used alone or blended with other Dr Sebagh serums. It works particularly well with hydrating, anti-ageing and brightening formulas as part of a personalised skincare routine.

When should I use Signature Serum in my routine?

Apply Signature Serum after cleansing and before your moisturiser. It can be used both morning and night for optimal results.

Does Signature Serum help with environmental damage and pollution?

Yes, the formula includes anti-pollution technology that helps protect the skin from environmental aggressors such as pollution and oxidative stress, which are key contributors to premature ageing.

Is Signature Serum suitable for mature skin?

Yes, Signature Serum is particularly beneficial for mature skin or anyone experiencing loss of firmness, elasticity or advanced signs of ageing.

Can Signature Serum be used with retinol or vitamin C?

Yes, Signature Serum works well alongside active ingredients such as retinol and vitamin C. It helps support the skin barrier and improve tolerance, making it an excellent addition to a results-driven skincare routine.

How long does it take to see results?

Skin can appear more hydrated, smooth and radiant almost immediately. Improvements in firmness, elasticity and overall skin quality become more visible with consistent use over time.

Does Signature Serum help support the skin barrier?

Yes, the formula contains essential fatty acids and microbiome-supporting ingredients that help strengthen the skin barrier, reduce moisture loss and improve overall skin resilience.

Signature Serum
Signature Serum30ml (Regular) / With box Sale price£475.00

Compare With...

Signature SerumSignature Serum
  • Cellular Longevity Biotechnology

    Pioneering actives combat nucleus ageing and extend DNA lifespan for younger-behaving skin.

  • Works With Your Skin's Biological Clock

    Syncs with the skin's overnight restorative cycle for maximum regenerative results while you sleep.

  • Delays Cellular Ageing at the Source

    Prevents Telomere shortening to support optimum cell metabolism and long-term skin renewal.

  • Anti-Pollution Shield

    Biosaccharide Gum-4 forms a protective matrix to shield skin from pollutant particles and external aggressors.

  • Targets Dynamic Wrinkles & Expression Lines

    A Botox-like peptide complex reduces muscle contraction for visibly smoother skin.

  • Intensive Treatment for Mature Skin

    Can be used daily, or as a concentrated 4-week course designed for advanced signs of ageing and loss of firmness.

  • 24K Gold & Platinum Nano-Technology

    Precious metals inspired by the Nefertiti Lift deliver visible firming and lifting.

  • Instant Golden Radiance

    Subtle light-reflecting gold pigments illuminate and brighten from first application.

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